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The revised ACS Trauma Quality Programs (TQP) Best Practices Guidelines for the Management of Traumatic Brain Injury includes new evidence and novel insights. An international multidisciplinary panel composed of widely recognized experts in all aspects of TBI care was assembled. Revisions include renaming and expansion of some sections, as well as the addition of the following new sections: imaging, blood-based biomarkers, pharmacologic management, rehabilitation, and systems of postacute care. The aim is to present a comprehensive but practical guide for the management of patients with TBI. Best practices can improve standards of care as well as patient outcomes.