Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis

Frederick A Zeiler, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Marcel Aries, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, David K Menon

Background

Impaired cerebrovascular reactivity in adult traumatic brain injury (TBI) is known to be associated with poor outcome. However, there has yet to be an analysis of the association between the comprehensively assessed intracranial hypertension therapeutic intensity level (TIL) and cerebrovascular reactivity.