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Sanjeev D Nandedkar, Ph.D.
Abstract
Importance When a motor nerve is stimulated at supramaximal intensity, all axons in the nerve depolarize. The resulting action potentials (APs) propagate to the muscle(s) innervated by the nerve, e.g. to the abductor pollicis brevis (APB) muscle after median nerve stimulation (Figure 1, Green arrow). The muscle fibers respond by producing their own AP that propagates to both tendons. The muscle fiber APs can be recorded using a surface electrode. The summated APs of all muscle fibers is called its compound muscle action potential (CMAP) or the ‘M’ response (Figure 1D) (Barkhaus et al, 2024).
