Presentation and Workup of Seronegative Myasthenia Gravis

Myasthenia Gravis (MG) is a common autoimmune disease affecting neuromuscular signaling, which can manifest subtly as fluctuating ptosis or as severely as respiratory failure. Accurate diagnosis of myasthenia requires identifying subtle physical exam findings and correlating them with laboratory results and electrophysiologic data. This presentation reviews the common presentation of myasthenia gravis, the diagnostic work up, and the evaluation of suspected seronegative patients.

Learning Objectives:
1. Review the physiology of the neuromuscular junction.
2. Review the presentation, and serologic and electrophysiologic workup of myasthenia gravis.
3. Discuss the differential of seronegative myasthenia gravis.
4. Discuss the role of single fiber EMG in the evaluation of seronegative myasthenic patients