How to Interpret SEEG Recordings

SEEG interpretation relies on the compartmentalisation of the epileptogenic region into lesional, irritative, and epileptogenic zones to differentiate interictal and ictal abnormalities. This approach avoids any bias in localisation, i.e. causing confusion between lesion and epilepsy, or between spikes and seizures. We will review what these different terms mean, which are the relevant biomarkers that help to differentiate these 3 zones, what are their causal relationship, and how their identification then allows, through their 3D representation, a careful individualised planning of the surgical resection.