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LL was a term male infant transferred from an outlying hospital with respiratory distress and apnea. Mother was G1, P0 and GBS negative. She was admitted for induction at 39½ weeks gestation after an uneventful pregnancy until pregnancy-induced hypertension appeared a few days prior to delivery. Membranes were ruptured 28 hours prior to delivery; fluid was clear. She developed a fever of 100.8 degrees during labor, while receiving epidural analgesia. There was no evidence of fetal distress. A single dose of Ancef was given, then C-section was performed for failure
to progress.
Apgar scores were 8 and 8; birth weight was 3030 grams, with symmetrical OFC and length measurements. The baby required supplemental O2 in the delivery room, then continued to have mild grunting and tachypnea in the nursery. He was placed in hood O2, and stabilized in 36% O2. A blood culture and CBC wereobtained, and he was started
Please download following .PDF to view the full clinical case study.
Robert White, MD
Director, Regional Newborn Program, Memorial Hospital
South Bend, IN, USA
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This presentation provides a comprehensive review of the 2025 ILAE updates to both the classification of epileptic seizures and epilepsy syndromes. The session will cover the taxonomic framework for seizure
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This presentation provides a comprehensive review of the 2025 ILAE updates to both the classification of epileptic seizures and epilepsy syndromes. The session will cover the taxonomic framework for seizure classification—including the use of consciousness as a classifier, the distinction between observable and non-observable seizure types, and the incorporation of newly recognized entities—as well as the updated approach to syndrome diagnosis across the lifespan. Emphasis will be placed on practical application in clinical care, with case-based examples illustrating how accurate seizure and syndrome classification inform etiology-driven diagnosis, therapeutic choices, and prognostic counseling. Considerations for use in resource-limited settings, research, and policy development will also be discussed.
Learning Objectives:
1. Summarize the 2025 ILAE operational classification of seizures and epilepsy syndromes, including the hierarchical structure and key terminology updates.
2. Differentiate seizure types using the revised criteria for consciousness, observable manifestations, and specific semiologic features.
3. Recognize the major electroclinical syndromes across neonate, infantile, childhood, adolescent, and adult onset groups, and understand their etiologic, prognostic, and therapeutic implications.
4. Integrate seizure classification with syndrome diagnosis to improve diagnostic precision, guide investigations (e.g., genetics, imaging), and inform treatment selection.
5. Apply the updated classifications to real-world clinical scenarios, research studies, and multidisciplinary care planning, including communication with patients, families, and policymakers.
6. Evaluate how these classification updates enhance global harmonization, support education, and align with precision medicine initiatives in epilepsy.
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Nicola Specchio
Nicola Specchio
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Nicola Specchio is Chair of Neurology, Epilepsy and Movement Disorders Unit at Bambino Gesù Children’s Hospital, and Director of Research Unit on Neurological and Neurosurgical Diseases in Rome, Italy, and Guest Professor in Pediatric Neurology at University of Leuven, Belgium.His main interest lies with seizure semiology and the classification of epileptic seizures and syndromes, drug resistant epilepsies, developmental and epileptic encephalopathies. Prof Specchio published more than 280 papers in many international journals and is principal investigator in different clinical trials in patients with rare and complex epilepsies and Developmental and Epileptic encephalopathies.Prof Specchio was recipient of the Young Investigator Award from the Commission of European Affair of the International League Against Epilepsy (2016) and of the “John Stobo Pritchard Award” from the International Child Neurology Association (ICNA) (2020). In 2021 he received the Ambassador for Epilepsy Award from the International Leagues Against Epilepsy.Prof Specchio is currently Past-Chair of the ILAE Terminology Commission, and since 2020 member of the Global Advocacy Council of the International League Against Epilepsy (ILAE). He is also Chair of the International League Against Epilepsy (ILAE) Europe, and board member of the of the International Child Neurology Association (ICNA), and of the Italian Chapter of the ILAE.
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