- Version
- Download 8
- File Size 429.00 KB
- File Count 1
- Create Date November 16, 2023
- Last Updated November 16, 2023
File | |
---|---|
Cortical spreading depression occurs during elective neurosurgical procedures |
Cortical spreading depression occurs during elective neurosurgical procedures
Andrew P Carlson, C William Shuttleworth, Brittany Mead, Brittany Burlbaw, Mark Krasberg, Howard Yonas
Abstract
OBJECTIVE: Cortical spreading depression (CSD) has been observed with relatively high frequency in the period following human brain injury, including traumatic brain injury and ischemic/hemorrhagic stroke. These events are characterized by loss of ionic gradients through massive cellular depolarization, neuronal dysfunction (depression of electrocorticographic [ECoG] activity) and slow spread (2-5 mm/min) across the cortical surface. Previous data obtained in animals have suggested that even in the absence of underlying injury, neurosurgical manipulation can induce CSD and could potentially be a modifiable factor in neurosurgical injury. The authors report their initial experience with direct intraoperative ECoG monitoring for CSD.