Role of transcranial Doppler ultrasonography in cerebrovascular disease

Course introduction:
Electro-clinical phenotyping is not out-dated – from seizure type and EEG pattern to syndrome diagnosis and etiology in developmental and epileptic encephalopathies in infancy.
Accurate diagnosis of seizure types is particularly challenging in neonates and infants, essential together with electroencephalographic findings and clinical context for epilepsy syndrome diagnosis and guidance towards etiology, treatment choice and prognosis, even in the era of rapidly increasing knowledge in genetics.

Learning Objectives:
At the conclusion of this seminar the participants will be able to:

• Recognize the different seizure types and EEG patterns present in developmental and epileptic encephalopathies in infancy.
• Understand the necessary recording techniques in this age group.
• Understand the value of electro-clinical phenotyping for differential diagnosis and clinical management.

Course introduction:
This session, presented by Dr. David Auerbach, an assistant Professor of Pharmacology at SUNY Upstate Medical University will discuss the development of a methodology to evaluate the neuro-cardiac-respiratory function. Specifically, attendees will learn to about a non-invasive system to simultaneously acquire video-EEG-ECG-oximetry-capnography recordings from conscious restrained animals. This novel recording system establishes a platform to test the efficacy and safety of therapeutics and can capture the complex cascade of multi-system events that culminate in sudden death. In addition to outlining the methodology for data acquisition, the discussion will include the analytical approaches for examining neuro-cardiac-respiratory function and pathologies.

Learning Objectives:
At the conclusion of this seminar the participants will be able to:

• It is critical to take a multi-system approach to examining the cascade of systemic changes that surround seizures.
• Discuss the development of a non-invasive system to acquire simultaneous video-EEG-ECG- oximetry-capnography recordings from conscious restrained animals.
• Learn about analytical approaches for examining neuro-cardiac-respiratory function and pathologies.